The other day the Globe ran a story on Maryland-to-Mass emigre Jeph Jacques and his creation Questionable Content. There are so many webcomics out there that it's a little difficult to stand out. It's a good thing that QC has succeeded where others have failed.
If Jacques' work is likely to be confused with anyone else's, it's RK Milholland's Something Positive. Both are set in the world of contemporary twenty-somethings, but QC is probably a little sunnier that s*p. The flights of fancy elements are quite distinct as well. Anyway, the world must be broad enough to accomodate both.
Very different, but well worth the time to seek it out, is Josh Pasto's The Other Kids. Currently "Kids" is showing on gocomics.com's Comics Sherpa service. It's there to get noticed, and may if it's lucky appear in newspapers in a few years. You know, if there are newspapers in a few years. Anyway, Pasto has a fresh and mordant take on childhood long after I would have thought that vein was fully tapped. As seen in the example below, he's also got a sharp and forward eye for design.
The way he keeps the upper right of the panel "clean" until he's ready to use it suggests a sophisticated Japanese influence. More power to him.